Former congresswoman Marjorie Margolies will not be making a return to Congress next year after a 20-year absence.

Margolies, the mother-in-law of Chelsea Clinton, was defeated in the Democratic primary for the U.S. House in Pennsylvania's 13th District Tuesday by state Rep. Brendan Boyle, who was carrying 58 percent of the vote when the Associated Press called the race for him with most precincts reporting. Margolies was second with 22 percent.

Boyle had strong backing from organized labor, which allowed him to overcome Margolies's high-profile support from Bill and Hillary Clinton, who helped her raise money. Bill Clinton even cut an ad for Margolies.

Boyle will be widely favored to win the general election. In 2012, President Obama won 66 percent of the vote in the 13th District, which encompasses Philadelphia and some of its suburbs.

The district is currently represented by Rep. Allyson Schwartz (D), who vacated the seat to run for governor.

Physician Val Arkoosh was on pace to finish third while state Sen. Daylin Leach was headed for a fourth-place finish.

Margolies lost her seat in Congress in the 1994 midterms mainly because of her vote for then-President Clinton's economic plan.