U.S. Senator Rand Paul (R-KY) (REUTERS/Yuri Gripas)

Sen. Rand Paul (R-Ky.) says he supports opening up relations with Cuba, a position that that puts him at odds with much of the would-be Republican presidential field.

“The 50-year embargo just hasn’t worked,” Paul told Tom Roten of WVHU in Huntington, West Virginia. "If the goal was regime change, it sure doesn’t seem to be working, and probably it punishes the people more than the regime because the regime can blame the embargo for hardship."

He added: “In the end, I think, probably, opening up Cuba is probably a good idea."

President Obama announced Wednesday that the United States would reopen its embassy in Havana and ease restrictions on travel and commerce with Cuba.

Other potential White House hopefuls have spoken out against Obama's decision. Sen. Marco Rubio (R-Fla.), Sen. Ted Cruz (R-Tex.) and Louisiana Gov. Bobby Jindal (R) took issue with it. So did former Florida governor Jeb Bush (R).

New Jersey Gov. Chris Christie (R) has not weighed in.

On the Democratic side, presumed frontrunner Hillary Clinton said she supports Obama's decision.