During Thursday night's GOP debate, Donald Trump was asked by Megyn Kelly about his unfiltered approach to public remarks--particularly when they are addressed to women. His response? A swipe at Rosie O'Donnell:

Businessman Donald Trump defended his controversial comments regarding women during the first Republican presidential debate of the 2016 election cycle. (Fox News Channel)

He's gotten into Twitter fights with O'Donnell before, taking swipes at her partner as well as her weight and calling her a loser.

O'Donnell wasted no time in responding: