He said that Clinton is using her gender to pander to the electorate, and that the "woman card" just "may be enough" for her.
"I’d love to see a woman president, but she’s the wrong person. She’s a disaster," Trump said. The businessman said he does plan to make women some of his top advisers if he is elected.
"I would have women, I would have the most capable people on my Cabinet," he said.
Trump has a history of making incendiary remarks about women. Last year, he said "Fox News" anchor Megyn Kelly had "blood coming out of her wherever" after she questioned him about his history of calling women "disgusting animals" and "dogs." Last month, he retweeted an unflattering image of rival Ted Cruz's wife contrasted with his own wife, a retired model.
When Kelly questioned him about his comments, Trump shot back, "Only Rosie O'Donnell."
In the interview with "Fox and Friends" on Tuesday, the businessman went after O'Donnell and actress Whoopi Goldberg, who said she would leave the country if Trump is elected.
Goldberg leaving "would be a great, great thing for our country," he said. "We'll get rid of Rosie. … now I have to get elected, because I'll be doing a great service to our country."
Trump also had words for actress Lena Dunham, who said she would move to Vancouver if Trump is elected.
"She’s a B actor and has no, you know, mojo," Trump said.