Casino mogul Sheldon Adelson and his wife Miriam refused to see Sen. Ted Cruz Wednesday night. (Jeff Scheid/Las Vegas Review-Journal via AP, Pool)

CLEVELAND — Sen. Ted Cruz infuriated a lot of Republicans in the Quicken Loans Arena Wednesday night when he refused to endorse Donald Trump, but perhaps he will most regret offending two of them.

Billionaires Sheldon and Miriam Adelson refused to let the senator from Texas enter their donor suite after his controversial address, according to a person familiar with the circumstances. CNN first reported the episode.

It was a pointed rebuff of a politician who has methodically cultivated the support of the Las Vegas Sands chairman and his wife for years, and who was once considered a strong contender to get their backing in the 2016 White House contest.

The Adelsons, who spent more than $92 million supporting Republicans in the 2012 elections, have approached this campaign with more caution, holding back from picking a candidate during the primaries. But this spring, they signaled they would back Trump. And on Wednesday night, Adelson adviser Andy Abboud made it official, tweeting a photo of the couple and the candidate together.