Speaking shortly before Romney on Thursday night, Eastwood gave a much-buzzed-about address in which he used an empty chair to play the part of President Obama.
Emanuel, who served as Obama's chief of staff in 2009 and 2010 before leaving the White House to run for mayor, said Romney's speech was "devoid or vacuous of any ideas."
Speaking on CBS' "Face The Nation," Obama's deputy campaign manager Stephanie Cutter added to the Democratic criticism of the GOP convention.
"It was a week of personal attacks, empty platitudes, and the one thing that you were left with is that they really think that lying is a virtue," said Cutter.
The mayor also sought to present the election as a choice between candidates with very different governing philosophies.
"This is an election about a clear choice," Emanuel said.
"People want to know about the first term? Very simple," he said. "General Motors is alive and well, and Osama bin Laden is not."
Updated at 11:59 a.m.