The Kennedys have held no seats in Congress -- for the first time in decades -- since Sen. Ted Kennedy (D-Mass.) died in 2009 and Rep. Patrick Kennedy (D-R.I.) retired in 2010.
Elsewhere in Massachusetts, both Reps. Richard Neal (D) and Bill Keating (D) survived in redrawn districts against significant opposition. Keating, a freshman, had the closer call, taking about 60 percent of the vote against Bristol County District Attorney Sam Sutter.
In the state's Senate race, Elizabeth Warren (D) had already won her party's nomination at the state party convention earlier this year and faced no opposition. She is running hard against Sen. Scott Brown (R-Mass.) in a top general-election race and addressed the convention on Wednesday.