With the launch of a new Republican effort to give a boost to electable Senate candidates, some conservatives are already expressing distaste for what they see as establishment intrusion.

Comedy Central's Stephen Colbert weighed in on the matter during "The Colbert Report" on Tuesday, taking shots at both sides of the GOP divide. He noted that it wasn't just conservative Republicans who lost in 2012. And later, he quipped that messing with the tea party could mean ending up "like the last candidate they targeted for destruction: Barack Obama":