Not to mention the child sex abuse scandal.
Here's a sampling of the awkward and potentially problematic issues that Winfrey might have to explain on the campaign trail.
Oprah and the child sex abuse scandal
Remember the headache the defunct Trump University became for its namesake during his campaign? Some might prefer to forget the cascading disasters of the Oprah Winfrey Leadership Academy for Girls.
Winfrey called the sprawling, $40-million complex her “gift” to poor South African girls when it opened in 2007 — complete with a yoga studio and beauty salon. She initially had to defend the luxurious complex against accusations that it looked elitist in a country wracked by poverty.
She defended the school in her typical heartwarming style: “If you are surrounded by beautiful things and wonderful teachers who inspire you, that beauty brings out the beauty in you,” Winfrey told reporters before the grand opening.
The girls had “never been told they are pretty or have wonderful dimples,” she said. “I wanted to hear those things as a child.”
Several months later, a dorm matron was arrested and accused of sexually abusing at least half- a-dozen seventh- and eighth-graders.
Oprah was reportedly heartbroken. She cried for half an hour, she told reporters in a news conference after the matron's arrest. She accused school officials of covering up the scandal. They told the girls to “put on happy faces,” Winfrey said.
She dismissed the head mistress and promised to clean house at the academy.
But less than two years later, with the dorm matron's trial still pending, several girls were suspended or expelled after accusations that they tried to force other students into sexual and romantic relationships.
And then the original accusations began to unravel.
The next year, the Guardian reported, Oprah settled with the headmistress, who had accused her of defamation by suggesting that she knew of the dorm matron's actions.
A few months after that, the dorm matron was acquitted of all charges, the Guardian wrote. A judge had found the girls' accusations self-contradictory and not credible.
The matron told reporters that her life had been ruined. She was broke, unemployed and said she didn't know if she could ever forgive Winfrey, who continued to stand by the girls' accusations.
The academy continues to operate. It recently celebrated its 10th anniversary with a scandal-free story in Variety, which notes Winfrey's advice for the girls: “I want you to be president of your own life.”
Oprah turned a cancer patient on to junk science
If Winfrey becomes president, she would have enormous influence over American health care, including nominating the surgeon general and health secretary.
Today, as The Washington Post wrote, Oz has his own show and may be the country's most influential physician. And he regularly uses that influence to promote treatments with no scientific basis, including, literally, “magic” beans.
Oz may not necessarily be politically toxic — Trump appeared on his show during the 2016 campaign — but he's become a pariah in the medical community. Winfrey booted him from her media network two years ago after a group of physicians accused him of “quack treatments.”
Nor is he the only accused quack Winfrey has embraced: As the Guardian wrote, she's been blamed for boosting Jenny McCarthy's anti-vaccine crusade. And Winfrey has repeatedly plugged a mystical self-help system called “The Secret,” which claims that thinking good thoughts (and buying DVDs) can cure emotional, financial and physical problems.
Winfrey's first show about “The Secret” helped make a believer of Kim Tinkham, who had recently been diagnosed with breast cancer. She told Winfrey in 2007 that the system had inspired her to ignore her doctors, who told her she needed immediate surgery and treatment. “I've decided to heal myself,” Tinkham said.
Winfrey tried to talk her out of it. “I'm really happy the message, or certainly some of the message, is reaching mass consciousness,” she said. But Tinkham could think healing thoughts and still get a partial mastectomy.
The Washington Examiner reported that Tinkham died three years later.
Oprah caused a hamburger panic
Most people assume Winfrey — a backer of former president Barack Obama and Hillary Clinton — would run as a Democrat. So she'd certainly need to win California, or Texas if she somehow ran as a Republican. Both happen to be big beef states. The latter was also the site of Winfrey's infamous beef lawsuit.
It began with an episode of “The Oprah Winfrey Show” in 1996, amid widespread fears of so-called mad cow disease, a potentially fatal illness that humans can catch by eating certain organs of infected cattle.
Though the disease's spread had actually peaked a few years earlier, according to the Centers for Disease Control and Prevention, Winfrey brought a vegetarian activist onto her show — and this happened:
“You said this disease could make AIDS look like the common cold,” Winfrey told the activist, according to the Associated Press.
“Absolutely,” the activist replied.
“It has just stopped me from eating another burger!” Winfrey exclaimed, and her audience applauded.
Ranchers said beef prices crashed to a 10-year-low the next day.
A judge later downgraded the case to a defamation suit, but Winfrey was forced to relocate her show to Amarillo, where her fans packed the street outside the courtroom during the 1998 trial.
A jury eventually decided that Winfrey had not been trying to sabotage the beef industry. Her fans drank champagne outside the courthouse, and the talk show host refused once again to eat a burger.
Meat lovers remembered the spectacle for decades. “Why Does Oprah Continue to Bully Beef?” Beef Magazine wrote several years ago, and accused Winfrey of using her magazine to publish a hit piece against factory farms, of which the swing states boast more than a few.
Oprah defended a fake book
With the beef wars behind her, Winfrey returned to her staple brand of positivity, sometimes tinged with tragedy.
In fall 2005, she brought author James Frey onto her show, who had written a harrowing memoir about overcoming alcohol and drug addiction.
“If you've ever had to live through this with somebody you love, here is a story that was written for you,” Winfrey told her viewers.
The rest of the segment was filled with passages from Frey's book, “A Million Little Pieces”:
Frey regaining consciousness in an airplane with no memory and missing teeth; Frey getting dental surgery without anesthesia; Frey freebasing cocaine and “snort[ing] glue.”
“I heave and it comes,” Frey recited from the book. “The burning vomit comes and comes again and again and again.”
Winfrey enthusiastically recommended “A Million Little Pieces” for her book club. It sold more than 2 million copies over the next two months, the New York Times reported.
Then reporters looked into Frey's stories and forced him to admit that he'd made many of them up.
Where he had written about getting high, driving a car into a police officer, fighting with the officer and spending three months in jail, police said, Frey had actually run his tire over a curb and politely paid bail for driving under the influence, CNN reported.
Where Frey wrote of being blamed for a teenager's fatal car accident, The Post wrote, the girl's parents could recall nothing of it.
Winfrey stood by the author, even after he admitted to exaggerating many stories. “What is relevant is that he was a drug addict who spent years in turmoil,” she told Larry King. “It seems to be much ado about nothing.”
Now critics turned on Winfrey, too. A Washington Post writer called her “deluded.” After a few days of humiliation, she invited Frey back on her show and, by common consensus, absolutely shredded him.
Still, the scandal did not end. The next year, Winfrey was back on King's show, denying that she had cruelly “annihilated” the author she once built up. In 2011, more than five years after the initial plug, Winfrey invited Frey onto her show yet again and apologized to him “for my lack of compassion.”
Some noted at the time that Frey had a new book coming out.
Oprah thinks some Americans need to die
Winfrey was promoting her most recent film, “The Butler,” in 2013 when she talked to the BBC about racism. The original interview seems to have disappeared online, but some of her words will live on:
“There are still generations of people, older people, who were born and bred and marinated in it, in that prejudice and racism,” Winfrey said, according to MSNBC. “And they just have to die.”
But right-leaning sites accused her of playing race politics to sell movie tickets.
Anticipating the deaths of any potential voters, even old racists, can't lend itself to a positive presidential campaign.
Oprah palled around with Harvey Weinstein
Speaking of “The Butler,” it was co-produced by Harvey Weinstein, the movie mogul now accused of serial sexual assault. His fall from grace last year helped expose a culture of predation on women in Hollywood and inspired Winfrey's Golden Globes speech, which may in turn launch her presidential campaign.
But Weinstein's behavior was reportedly an open secret in the industry, which might make all the photos of Winfrey schmoozing around with him a political problem.
Unlike with Frey, Winfrey at least never publicly defended Weinstein after the accusations went public. Rather, she condemned his “hideous behavior.”
Still, her spokesman had to deny a TMZ report that Winfrey urged Weinstein to defend himself against the scandal. And in November, actress Kadian Noble told reporters that Weinstein had seduced her, in part, by introducing her to Winfrey and Naomi Campbell.
This led to a headline on Page Six: “Weinstein used Oprah and Naomi to seduce me.”
Fair or not, that's the stuff attack ads are made of.