At the CBS Republican primary debate in Greenville, S.C., candidates weighed in on the passing of Supreme Court Justice Antonin Scalia. (CBS)

The ninth Republican presidential debate was in many ways the nastiest of the campaign, complete with raised voices, name calling, and criticism of family members Saturday night in South Carolina.

Donald Trump took sharp aim at former President George W. Bush’s foreign policy and his brother, former Florida governor Jeb Bush, rebuked him sharply. Sen. Ted Cruz called Sen. Marco Rubio soft on immigration and Rubio accused Cruz of not telling the truth. Trump flatly called Cruz the “single biggest liar” on stage while Cruz told him not to interrupt.

The biggest news story heading into the debate was the death of Supreme Court Justice Antonin Scalia. But after consensus support at the top of the debate for a conservative to succeed him, Scalia’s death moved into the background as national security, immigration and the candidates’ records dominated the discussion.

At one point, Cruz accused Trump of glossing over his liberal past on Planned Parenthood and abortion. Trump angrily fought back.

“Why do you lie?” Trump asked him.

Donald Trump got into it with pretty much every other candidate at the Feb. 13 CBS News GOP debate. (Peter Stevenson/The Washington Post)

The two started talking over each other at another point and Cruz said: “Adults learn not to interrupt.” He also warned that with Trump, the country would get “liberal” nominees for the Supreme Court.

Trump blamed Cruz and George W. Bush -- who he bashed routinely during the debate -- for the nomination and support of Chief Justice John Roberts.

Earlier, Cruz and Rubio hit each other hard on immigration, with Cruz decrying the “Rubio-Schumer amnesty plan” and Rubio accusing Cruz of lying.

Cruz argued Rubio has been too soft on immigration and disparaged him for supporting a path to citizenship for illegal immigrants. Rubio struck back by arguing that Cruz once supported legalization.

Things got personal when Cruz pointed to an interview Rubio did on Spanish-language television as evidence he would not rescind executive actions taken by President Obama.

“I don’t know how he knows what I said on Univision because he doesn’t speak Spanish,” Rubio shot back.

Republican presidential contender Ted Cruz and CBS GOP debate host John Dickerson sparred over when Supreme Court Justice Anthony Kennedy was nominated and confirmed at the CBS News GOP debate on Feb. 13. (CBS)

Minutes later, Jeb Bush and Trump clashed on immigration. Trump said Bush had the weakest immigration record of all the candidates.

Bush pivoted to other issues in his counterattack against Trump, saying it is “weak to disparage women. It’s weak to disparage Hispanics.”

Trump also hit former President George W. Bush hard, directing some blame at him for the Sept. 11, 2001 terror attacks and saying he erred badly by invading Iraq in 2003.

Trump clashed sharply on the issue with Jeb Bush, who came out swinging against Trump’s foreign policy.

Bush accused Trump of dangerously advocating too cozy a relationship with Russian President Vladimir Putin in the Middle East. As Trump defended himself, he was booed by the crowd. He argued the people who were booing him were Bush’s “special interests and lobbyists.

Trump later hit George W. Bush for making a “mistake” invading Iraq.

Jeb Bush counter-punched: “I could care less about the insults Donald Trump gives to me. ... I am sick and tired of him going after my family.”

“The World Trade Center came down during the reign of George Bush. He kept us safe?” Trump said. “I lost hundreds of friends” in the 9/11 terrorist attack.

Bush dismissed Trump’s foreign policy knowledge: “This is from a guy who gets his foreign policy from the shows.”

And in an exchange with Trump, Rubio blamed the Sept. 11 attacks on former President Bill Clinton. “The World Trade Center came down because Bill Clinton didn’t kill Osama bin Laden when he had the chance to kill him,” Rubio said.

Earlier, Trump said that if he were president now, he would try to nominate a successor for deceased Supreme Court Justice Antonin Scalia, but he said it is incumbent on Republican Senate leaders to prevent the confirmation of President Obama’s eventual nominee.

“I think it’s up to Mitch McConnell and everyone else to stop it. It’s called delay, delay, delay,” he said.

Other candidates at the debate said that Obama should not nominate a new justice, praised Scalia’s service on the court and urged a conservative replacement.

“Barack Obama will not have a consensus pick,” said former Bush.

“I just wish we hadn’t run so fast into politics,” said Ohio Gov. John Kasich.

Texas Sen. Ted Cruz said: “The Senate needs to stand strong.”

Scalia, who was beloved by conservatives, died hours before the debate began. His death and the subject of who will replace him immediately become major topics of conversation in the debate and in the broader campaign. After the candidates took the stage, debate moderator John Dickerson called for a moment of silence for Scalia.

Adding to the testy atmosphere Saturday, Trump issued a statement accusing the Republican National Committee of “illegally” putting out a fundraising notice using his name before withdrawing it “at my insistence.” An RNC aide said the notice Trump was citing was related to a straw poll where participants were asked to donate once they picked a candidate.

“The straw poll allows supporters of all the candidates to help contribute to the presidential trust that ensures our nominee has the $23 million of RNC funds to take on Hillary Clinton or Bernie Sanders,” said RNC chief strategist and communications director Sean Spicer.

Saturday’s debate was expected to test whether Rubio, who was ridiculed for mechanically repeating himself in the previous meeting, can regain his footing after a fifth-place finish in New Hampshire.

Several one-on-one competitions were expected to escalate on stage, because fewer candidates is likely to mean more talking time for each one. Among them: Trump vs. Cruz Rubio vs. Cruz, Rubio vs. Bush, and Bush vs. Kasich.

The two-hour clash, which CBS News is hosting, started at 9 p.m. Eastern time. This is the last debate before the Feb. 20 South Carolina primary.

Trump once again stood at the middle of the stage. He held a commanding lead in South Carolina, home to nearly 5 million people, including an eclectic mix of Republicans. There are many Christian conservatives, defense hawks and centrists in the state.

Trump released an ad this week focusing on his signature issue: immigration. The father of an African American teenager killed by an illegal immigrant explains why he supports Trump in the ad.

“Trump is the only one saying: You’re going to be dealt with. We’re going to enforce that,” Jamiel Shaw says in the ad. “We’re going to enforce that. That’s a beautiful thing.”

Trump has voiced hard-line positions on immigration, including banning all Muslims from entering the country over concerns about terrorism and creating a “deportation force” to remove undocumented immigrants.

But in genteel South Carolina, Trump’s challengers have taken aim at his brashness as much as they’ve targeted his policy ideas.

On the campaign trail this week, Rubio has criticized Trump for using crude language that he said he had to shield from his young sons. Right to Rise USA, a super PAC promoting Bush released an ad Friday calling Bush “the better man” and highlighting Trump’s personal attacks.

Rubio is trying to reignite a campaign that fell apart in the final days before the New Hampshire vote. He is showing a personal side he hopes will wipe away accusations that he is too robotic. He also has adopted a more aggressive posture, hitting not just Trump but Bush, whom he argues does not have any foreign policy experience.

Bush, who finished just ahead of Rubio in New Hampshire, is trying to edge ahead of the senator in the battle for the mainstream Republican mantle. A strong showing in South Carolina, where Bush’s father and brother won primaries, could deal a devastating blow to Rubio.

On Monday, former president George W. Bush plans to campaign with his brother at a rally in North Charleston, S.C., after mostly staying out of politics since he left the White House in 2009.

Rubio is not the only opponent Bush needs to worry about. Kasich, who finished a strong second in New Hampshire, has secured new financial support in recent days. He threatens to pull away some centrist Republicans also drawn to Bush.

Another battle that was raging heading into Saturday was the one between Trump and Cruz. Cruz’s campaign released a video this week that says Trump “pretends to be a Republican.” On Friday, Trump tweeted: “If @TedCruz doesn’t clean up his act, stop cheating, & doing negative ads, I have standing to sue him for not being a natural born citizen.”

Also on the stage is retired neurosurgeon Ben Carson, who has faded sharply after exploding onto the national political landscape last year. Carson is polling at the bottom of the field in South Carolina.

Jenna Johnson in Tampa, Philip Rucker in Greenville, Ed O’Keefe in Myrtle Beach, S.C., and Jose A. DelReal in Washington contributed to this report.