Week 5 was a rough one for several NFL quarterbacks, but no one had a worse go of it than Dak Prescott of the Dallas Cowboys, who suffered a possible season-ending ankle injury during a win Sunday over the New York Giants. He was replaced by Andy Dalton, signed in the offseason from the Cincinnati Bengals and now overseeing a highflying offense that is clinging to Super Bowl hopes.

According to the Cowboys, Prescott was to undergo surgery Sunday night for a compound ankle fracture and dislocation.

Elsewhere, Cleveland Browns quarterback Baker Mayfield injured his ribs during a win over the Indianapolis Colts and the San Francisco 49ers’ Jimmy Garoppolo was benched halfway through a stunning rout at the hands of the visiting Miami Dolphins. In addition, the Washington Football Team’s Kyle Allen suffered an arm injury, paving the way for Alex Smith to take his first snaps since a gruesome 2018 injury.

The most eye-opening win Sunday may have been posted by the Las Vegas Raiders, who went to Kansas City and handed the reigning Super Bowl champion Chiefs their first loss since Week 10 of last season. With their loss, the Giants fell to 0-5, as did the New York Jets and Atlanta Falcons.

What you need to know
11:51 p.m.
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After Dak Prescott’s injury, Andy Dalton engineers Cowboys’ win

The Dallas Cowboys’ game Sunday against the New York Giants in Arlington, Tex., will be remembered for the ankle injury suffered by quarterback Dak Prescott.

But backup Andy Dalton took over and managed to secure a 37-34 victory for the Cowboys.

Kicker Greg Zuerlein’s 34-yard field goal as time expired won it for the Cowboys. Wide receiver Michael Gallup made a superb catch along the sideline of a pass from Dalton for a 38-yard gain with three seconds left, setting up Zuerlein’s kick. Zuerlein’s 40-yard field goal had tied the score at 34 with just less than two minutes remaining.

Dalton, the former Cincinnati Bengals starter added in the offseason to back up Prescott, completed nine of 11 passes for 111 yards. With Prescott being taken to a nearby hospital after being taken from the field in a cart during the third quarter, the Cowboys become Dalton’s team for now. They improved their record to 2-3 and kept the Giants, now 0-5, winless.

11:42 p.m.
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Cody Parkey’s single-doink field goal seals win as Browns improve to 4-1

Things are going the Cleveland Browns’ way. How often has that been said over the years?

The Browns upped their record to 4-1 with a 32-23 triumph at home over the Indianapolis Colts.

The victory was sealed when kicker Cody Parkey connected on a 46-yard field goal with 21 seconds remaining, as the football clanked off the left upright and still went through. Yes, that’s the same Cody Parkey who once had a double-doink miss on a field goal try that would have won a playoff game for the Chicago Bears.

Colts quarterback Philip Rivers threw two interceptions in the loss.

11:37 p.m.
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Suddenly, the 49ers’ playoff hopes appear to be in jeopardy

Things can change quickly during an NFL season, and the San Francisco 49ers suddenly might have an uphill battle just to return to the playoffs, let alone to the Super Bowl. Instead of taking advantage of an early slate that might have resulted in a record of 4-1 or even 5-0, the team is 2-3 and staring at a much more imposing group of upcoming opponents.

Following their 43-17 loss at home to the Miami Dolphins, the 49ers are now set to face, in order: the Los Angeles Rams, New England Patriots, Seattle Seahawks, Green Bay Packers, New Orleans Saints, Rams again and then the Buffalo Bills. Those teams entered Sunday with a combined record of 19-5, as compared to the 4-15-1 mark posted by San Francisco’s first five foes, which included the Arizona Cardinals, New York Jets, New York Giants and Philadelphia Eagles.

Adding to the Niners’ uneasy situation is the fact that starting quarterback Jimmy Garoppolo was benched Sunday after a poor, two-interception first half. San Francisco Coach Kyle Shanahan said after the game that he pulled Garoppolo because the latter was still recovering from an ankle injury, so the benching is not expected to last, but the team’s struggles in the standings might.

10:46 p.m.
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Dak Prescott injured, leaves field on a cart with tears in eyes

Dallas Cowboys quarterback Dak Prescott was taken from the field on a cart after suffering an injury, apparently to his right ankle, in the third quarter of Sunday’s game against the New York Giants in Arlington, Tex.

Prescott appeared to have tears in his eyes as he was taken from the field, to supportive cheers from fans. Cowboys players and those in owner Jerry Jones’s private box also appeared emotional.

Prescott had his right ankle bent awkwardly as he was tackled at the end of a run.

Andy Dalton took over at quarterback for the Cowboys.

10:32 p.m.
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Browns, Colts trade return TDs

There haven’t been a ton of offensive fireworks so far between the Cleveland Browns and Indianapolis Colts, but the game just received a jolt of electricity. Two returns on consecutive plays delivered two quick touchdowns, one for each side.

First the Browns struck by picking off Colts quarterback Philip Rivers, who telegraphed a sideline throw to wide receiver T.Y. Hilton. Cleveland defensive back Ronnie Harrison Jr. read the play and pounced on the pass, then brought it the other way for a 47-yard score.

The Browns did not have long, though, to enjoy their 27-10 lead. The Colts’ Isaiah Rodgers took the ensuing kickoff 101 winding yards for an immediate response that trimmed his team’s deficit to 27-17.

10:12 p.m.
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Dak Prescott has touchdown catch for Cowboys on ‘Philly Special’ lookalike

The Dallas Cowboys got a touchdown against the New York Giants with a variation of the famed “Philly Special” gadget play that the Philadelphia Eagles once used against the New England Patriots in the Super Bowl when quarterback Nick Foles made a touchdown catch.

In the Cowboys’ version, tailback Ezekiel Elliott took a handoff from quarterback Dak Prescott and pitched the football to wide receiver Cedrick Wilson, who threw a touchdown pass to Prescott.

That came after the Giants had a touchdown pass on a successful fake field goal negated by an illegal-shift penalty.

The Cowboys lead the Giants, 24-20, at halftime. The Dallas defense had a touchdown on a return of a fumble by Giants quarterback Daniel Jones.

NFC East teams at least can’t go 0-4 on this day.

10:04 p.m.
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49ers bench Jimmy Garoppolo at halftime

Another week, another benching of a San Francisco 49ers quarterback, and another relief appearance by C.J. Beathard.

This time, though, the quarterback shown the pine was Jimmy Garoppolo, on whom the Niners bestowed a $137.5 million contract in 2018. Garoppolo was replaced Sunday at halftime, after he threw two interceptions while completing just 7 of 17 passes for 77 yards and a minuscule 15.7 passer rating, as his heavily favored team fell behind the visiting Miami Dolphins, 30-7.

Last week, Beathard came in for a struggling Nick Mullens during a home loss to the Philadelphia Eagles. Mullens was starting his second game in place of Garoppolo, who had been out with an ankle injury.

9:45 p.m.
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We have an early sprinkling of ‘Fitzmagic’ in San Francisco

Ryan Fitzpatrick isn’t quite ready to cede his starting spot to rookie Tua Tagovailoa, it would appear. The veteran quarterback served up a sizable sprinkling of “Fitzmagic” in the early going in San Francisco, as he led his Miami Dolphins to a 30-7 halftime lead over the heavily favored 49ers.

Through the first two quarters, Fitzpatrick completed 15 of 20 passes for 251 yards, two touchdowns and a 150.0 rating. Miami’s cause was also aided by a shaky first-half performance from San Francisco quarterback Jimmy Garoppolo, who threw two interceptions while completing just 7 of 17 passes for 77 yards and no scores.

During an unlikely career that has seen him play for eight teams in 16 seasons, Fitzpatrick has become known for alternating hot streaks with icy stretches that get him replaced under center and, soon thereafter, off to his next destination. Earlier this week, the Dolphins announced that Fitzpatrick would continue to be their starter through at least their Week 5 game, a tepid vote of confidence that was widely interpreted as setting the stage for the ascension of Tagovailoa, the No. 5 pick in the draft.

9:31 p.m.
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Falcons reportedly close to firing Dan Quinn

The speculation is intensifying that the Atlanta Falcons will fire Dan Quinn. Owner Arthur Blank has resisted making that move so far. But the Falcons’ record dropped to 0-5 with their loss Sunday to the Carolina Panthers.

The Athletic reported that the dismissal of Quinn is “all but finalized” and an announcement could come Monday or Tuesday.

Quinn would be the second NFL head coach fired this season. The Houston Texans beat the Jacksonville Jaguars on Sunday in Romeo Crennel’s debut as their interim coach after Bill O’Brien was ousted as the team’s head coach and general manager.

9:29 p.m.
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Michael Thomas to miss Saints’ game Monday night because of team discipline

New Orleans Saints wide receiver Michael Thomas will miss Monday night’s game against the Los Angeles Chargers because of a disciplinary issue, the team announced.

The Saints announced that the “change in game status is not injury related” but is based on “team discipline.”

ESPN reported that Thomas had a practice-field “altercation” with a teammate.

Thomas has not played since the season-opening game. He had been sidelined by an ankle injury.

9:15 p.m.
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Eagles’ WR Travis Fulgham bursts onto NFL scene

The Eagles lost Sunday to the Pittsburgh Steelers despite the considerable heroics of Philadelphia wide receiver … Travis Fulgham?

It’s a name unfamiliar to most football fans, but then again, Fulgham is used to defying expectations. After all, he had to walk on at Old Dominion after starring at Broad Run High in Northern Virginia, and he was cut by the Detroit Lions in August after they made him a sixth-round pick in 2019.

Fulgham was then claimed by the Green Bay Packers only to be quickly waived, but he landed with the Eagles and a rash of injuries to that team’s receiving corps thrust him into game action. The 6-foot-2, 215-pound 25-year-old caught his first NFL pass last week and turned his second into a go-ahead, 42-yard score against the San Francisco 49ers.

On Sunday, Fulgham went off against a tough Steelers defense, catching 10 passes for 152 yards and a touchdown in a 38-29 loss. That was the most receptions and second-most receiving yards of any player in the NFL’s early slate Sunday, ensuring Fulgham of making quite a name for himself.

8:45 p.m.
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Raiders outscore Chiefs in Kansas City

The Raiders’ Derek Carr outplayed the Chiefs’ Patrick Mahomes as visiting Las Vegas outscored Kansas City for an unexpected win, 40-32. The defending Super Bowl champion Chiefs had not lost since Week 10 of the 2019 season.

Mahomes had yet to be intercepted this season while throwing 11 touchdown passes through his first four games, but he was picked off with under six minutes left Sunday as he was trying to mount a comeback from a nine-point deficit. That interception was returned to the 2-yard line, at which point Raiders running back Josh Jacobs punched in a touchdown that all but clinched his team’s victory.

Carr completed 22 of 31 passes for 347 yards, three touchdowns, one interception and a passer rating of 126.7, and he hit wide receivers Henry Ruggs and Nelson Agholor for scoring plays of 72 yards and 59 yards, respectively. Mahomes, who had 340 passing yards but a rating of just 83.5, was not as sharp as usual, but the major culprit for the Chiefs’ loss arguably was a defense that did little to harass Carr or get the Raiders off the field.

8:39 p.m.
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Steelers are 4-0 for the first time since 1979

The Pittsburgh Steelers are 4-0 for the first time since 1979. They achieved it by beating the Philadelphia Eagles, 38-29, in Pittsburgh.

Wide receiver Chase Claypool scored four touchdowns. He ran for one and had three touchdown catches on passes by Ben Roethlisberger. Claypool had seven catches for 110 yards. It was a day for unheralded wideouts, as the Eagles’ Travis Fulgham had 10 catches for 152 yards and a touchdown.

Philadelphia’s record dropped to 1-3-1, still very much in the thick of the NFC East race.

8:24 p.m.
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Chase Claypool scores 4th TD

Chase Claypool is having himself a day, and then some. The rookie wide receiver for the Pittsburgh Steelers scored his fourth touchdown Sunday, further putting himself in some rarefied air in NFL annals.

Earlier in the game, Claypool became just the sixth rookie in league history to record two receiving touchdowns and a rushing touchdown in a single game (per ESPN). His fourth score came on a 35-yard pass from Steelers quarterback Ben Roethlisberger with just under three minutes left against the Philadelphia Eagles.

Only 15 times in NFL history has a player scored more than four touchdowns in a game. The Chicago Bears’ Gayle Sayers, who died last month at 77, and the Cleveland Browns’ Dub Jones share the record with six scores.