Bill Monbouquette, an All-Star pitcher who threw a no-hitter and had a 20-win season for his hometown Boston Red Sox, died Jan. 25 at a hospital in Boston. He was 78.

He had complications from leukemia, the Red Sox announced.

Mr. Monbouquette spent more than 50 years in professional baseball as a player, coach and scout. He was inducted into the Red Sox Hall of Fame in 2000.

Born and raised in nearby Medford, Mass., the right-hander was signed by Boston in 1955 and made his Red Sox debut three years later at age 21. He was selected to four All-Star teams, starting for the American League in 1960, and pitched a no-hitter in Chicago for a 1-0 win against the White Sox on Aug. 1, 1962.

Mr. Monbouquette spent the first eight of his 11 major league seasons with the Red Sox. He went 20-10 with a 3.81 ERA for Boston in 1963 and also pitched for the Detroit Tigers (1966-67), New York Yankees (1967-68) and San Francisco Giants (1968). He finished with a 114-112 record and a 3.68 ERA.

Former Boston Red Sox pitcher Bill Monbouquette poses for a photo at the annual Boston Baseball Writers of America awards dinner in Boston in this Jan. 31, 1964, file photo. (AP)

Nicknamed “Monbo,” he set a Red Sox record by striking out 17 batters in a 2-1 victory over the Washington Senators on May 12, 1961. The mark stood until Roger Clemens established a major league record with 20 strikeouts in a 1986 game against Seattle.

Mr. Monbouquette ranks seventh on the Red Sox career list with 96 wins and often visited Fenway Park in recent years, the team said.

After his playing career ended, he spent 38 years as a coach and scout with the Yankees, New York Mets, Toronto Blue Jays, and Tigers. He was the Mets’ pitching coach in 1982 and 1983. He retired from baseball in 2005 after working as a a pitching coach in the Tigers’ system. One of his protégés was Tigers pitching star Justin Verlander.

Survivors include his wife, Josephine Monbouquette; three children; and three grandchildren.