Noon Navy at ToledoESPNews, WFED-1500
Noon No. 11 South Carolina at TennesseeESPN
Noon Minnesota at NorthwesternESPN2
Noon Connecticut at CincinnatiESPNU
Noon No. 15 Georgia at Vanderbilt
WUSA-9, WJZ-13
Noon No. 22 Florida at No. 14 MissouriWDCW-50
Noon No. 16 Texas Tech at West Virginia
Fox Sports 1
Noon TCU at No. 21 Oklahoma State
Noon Purdue at Michigan StateBig Ten Network
Noon Villanova at New Hampshire
Comcast SportsNet
Noon SMU at MemphisMASN
Noon Southern Mississippi at East CarolinaMASN2
12:30 Syracuse at Georgia Tech
WDCA-20, WNUV-54

Florida travels to Missouri, the Gators’ farthest trip north since a loss at Syracuse in 1991. Neither team is particularly healthy. The Tigers lost quarterback James Franklin to a shoulder injury in last weekend’s upset of Georgia, while the Gators will be without second-leading rusher Matt Jones after he suffered a left knee injury in a loss to LSU. Florida has the nation’s third-ranked defense (235.3 yards per game), so Missouri quarterback Maty Mauk could have all he can handle in his first collegiate start.

3:30 Duke at VirginiaComcast SportsNet,
3:30 Maryland at Wake ForestESPNU,
3:30 Iowa at No. 4 Ohio StateWJLA-7, WMAR-2
3:30 No. 24 Auburn at No. 7 Texas A&M
WUSA-9, WJZ-13
3:30 No. 9 UCLA at No. 13 StanfordESPN2
3:30 No. 18 Oklahoma at KansasESPN
3:30 Indiana at MichiganBig Ten Network
3:30 Brigham Young at HoustonESPNews
3:30 North Texas at Louisiana Tech
CBS Sports Network

We haven’t heard much from Texas A&M quarterback Johnny Manziel since his offseason rumspringa, as he’s letting his play on the field do all the talking: 14 touchdown passes, five touchdown runs, 6.5 yards per carry. Last season against Auburn, he accounted for five touchdowns in the Aggies’ 63-21 win. Texas A&M hosts the Tigers this time around, hoping Manziel again does enough to overcome the team’s 113th-ranked defense. . . . UCLA travels to Stanford with its highest ranking since 2005. The Cardinal is coming off a loss to Utah, and it hasn’t lost consecutive games since 2009. The Bruins will need to perform more efficiently against Stanford then they did last weekend against California and its terrible defense. On three occasions, UCLA got inside the 10-yard line but had to settle for field goals.

7 Old Dominion at Pittsburgh
Comcast SportsNet Plus
7 Arkansas at No. 1 AlabamaESPN
7 No. 6 LSU at MississippiESPN2
7 Iowa State at No. 12 BaylorESPNU
7:30 USC at Notre DameWRC-4, WBAL-11
8 No. 5 Florida State at No. 3 Clemson
8 No. 25 Wisconsin at IllinoisBig Ten Network
8 Nevada at Boise StateCBS Sports Network
10 Washington State at No. 2 Oregon
Fox Sports 1
10:30 Oregon State at CaliforniaESPN2

And in the Game of the Night (Game of the Year?), we have Florida State-Clemson. Two teams with high-powered offenses? Check (the Seminoles are fourth nationally in yards per game, the Tigers are 13th). Two teams with stout defenses? Check (FSU is seventh in yards allowed per game, Clemson leads the nation with 4.0 sacks per game). Two teams with Heisman contenders? Check (Jameis Winston for the Seminoles, Tajh Boyd for the Tigers). Two teams that, um, struggled to beat Boston College? Check! Last weekend, the Tigers needed two fourth-quarter touchdowns to beat the Eagles, and the Seminoles trailed Boston College 17-3 in the second quarter Sept. 28 before Winston came to life and started doing Winston-type things. The winner of this one can likely pencil in a spot in the ACC title game and stay in contention for a BCS title game berth.

— Matt Bonesteel