Virginia Tech vs. Duke

Where: Thompson Field in Blacksburg, Va.

When: 4 p.m.

Records: Hokies 18-4-3, Blue Devils 9-8-6.

At stake: Berth in College Cup semifinals against Florida State or Boston College next Friday in Cary, N.C.

Outlook: The Hokies, one of four No. 1 seeds in the 64-team tournament, have reached the quarterfinals for the first time. In the regular season, they played Duke to a 1-1 draw in Durham, N.C. Freshman Murielle Tiernan, a two-time All-Met Player of the Year from Stone Bridge, and senior Jazmine Reeves have combined for 21 goals and 10 assists. Two of Duke’s three tournament matches have gone to penalty kicks.

Virginia vs. Michigan

Where: Klockner Stadium in Charlottesville.

When: 7 p.m.

Live video: www.virginiasports.com

Records: Cavaliers 23-1-0, Wolverines 18-3-1.

At stake: Berth in College Cup semifinal against North Carolina or UCLA next Friday in Cary, N.C.

Outlook: The Cavaliers, a No. 1 seed, are 17-0-0 at home with a 56-6 goal differential and have posted three consecutive home shutouts in the NCAA tournament. They have appeared in the quarterfinals four times in 12 years and are seeking their first semifinal berth since 1991. With 75 goals, Virginia is the national scoring leader. Michigan, guided by former U.S. national team coach Greg Ryan, has conceded 10 goals.

Georgetown vs. Michigan State

Where: Shaw Field in Washington.

When: 1 p.m. Sunday.

Live video: www.guhoyas.com

Records: No. 6 Hoyas 14-4-2, No. 11 Spartans 13-5-3.

At stake: Berth in quarterfinals next weekend against No. 3 Notre Dame or No. 14 Wake Forest.

Outlook: The Hoyas, second in the nation in goals allowed with nine, have conceded one goal in six matches and haven’t yielded multiple goals since Oct. 12. They are unbeaten in nine straight home matches, giving up three goals in that time. Senior Steve Neumann and sophomore Brandon Allen have combined for 21 goals. The Spartans (5-1-2 on the road) advanced with a 1-0 overtime victory over visiting Louisville.

Virginia vs. Marquette

Where: Klockner Stadium in Charlottesville.

When: 1 p.m. Sunday.

Live video: www.virginiasports.com

Records: No. 8 Cavaliers 11-5-5, No. 9 Golden Eagles 13-5-2.

At stake: Berth in quarterfinals next weekend against No. 1 UCLA or Connecticut.

Outlook: Virginia, a 2-0 winner over St. John’s in the second round, is seeking its first quarterfinal berth since winning the 2009 national title. Nine players have scored at least two goals, led by junior Eric Bird’s seven. The Cavaliers have gone to overtime nine times without a defeat (4-0-5). Marquette, the Big East champion, won the first tournament game in program history last weekend, defeating Akron in overtime.

Maryland vs. UC Irvine

Where: Ludwig Field in College Park.

When: 5 p.m. Sunday.

Live video: www.umterps.com

Records: No. 5 Terrapins 14-3-5, No. 12 Anteaters 15-4-3.

At stake: Berth in quarterfinals next weekend against No. 4 California or Coastal Carolina.

Outlook: Maryland carries an eight-game winning streak into its 12th consecutive round-of-16 appearance. After a sloppy start, the Terrapins have allowed more than one goal twice in 17 outings. Senior Patrick Mullins has converted 9 of 9 penalty kicks and recorded 15 goals overall. The Anteaters, the Big West champions, extended their winning streak to eight last week by defeating North Carolina, 1-0, on a goal with two seconds left.

Other round-of-16 games (Sunday): Penn State at No. 7 New Mexico, Stanford at No. 2 Washington.

— Steven Goff