Baltimore (3-1) at Kansas City (1-3) — 1 p.m., CBS
Kansas City leads the NFL with 15 turnovers and a minus-13 differential. Kansas City QB Matt Cassel has thrown seven interceptions and lost three fumbles. Chiefs RB Jamaal Charles leads the NFL in yards from scrimmage with 512. Ravens RB Ray Rice is second with 491. Baltimore is coming off a stretch of four games in 18 days.
Miami (1-3) at Cincinnati (3-1) — 1 p.m., CBS
Miami’s Ryan Tannehill threw for 431 yards in last week’s loss to Arizona, the second-most by a rookie QB in NFL history. Cincinnati leads the NFL
with 17 sacks. DT Geno Atkins leads all NFL interior linemen with five.
Cleveland (0-4) at New York Giants (2-2) - 1 p.m., CBS
The Browns have lost 10 straight games dating to last season. Their last win was against Jacksonville Nov. 20. Giants rookie David Wilson is third in the NFL, averaging 30.2 yards on kickoff returns.
Atlanta (4-0) at Washington (2-2) — 1 p.m., FOX
This game features the NFL’s top-rated passer in Matt Ryan (112.1 rating) and the league’s top-rated rookie in Robert Griffin III (103.2). The Falcons lead league with plus-10 turnover differential. They are only team yet to lose fumble this season. Washington’s Alfred Morris leads NFL rookies with 376 yards rushing. Washington is first team in NFL history with two rookies (Griffin, Morris) each with four-plus rushing TDs in team’s first four games.
Green Bay (2-2) at Indianapolis (1-2) — 1 p.m., FOX
Indy receiver Reggie Wayne needs two touchdowns to pass college teammate Edgerrin James (75) for third on franchise list, 64 yards from scrimmage to pass James (12,065) for No. 2 in franchise history.
Philadelphia (3-1) at Pittsburgh (1-2) — 1 p.m., FOX
The Steelers, who haven’t lost back-to-back games since 2009, are coming off a 34-31 loss to Oakland two weeks ago. The Eagles lead the NFL in yards per game differential, averaging 417.8 yards while giving up 298.3.
Seattle (2-2) at Carolina (1-3) — 4:05 p.m., FOX
Seattle RB Marshawn Lynch leads the NFL with 423 yards rushing and has at least 85 yards rushing in 12 of his past 13 games. Panthers QB Cam Newton’s 17 rushing TDs are the most by a QB in his first two seasons.
Chicago (3-1) at Jacksonville (1-3) — 4:05 p.m., FOX
The Bears lead the NFL with 14 takeaways, including five INTs vs. Dallas Monday night. Jags RB Maurice Jones-Drew needs 41 all-purpose yards to reach 12,000 and join Fred Taylor (13,632) and Jimmy Smith (12,875).
Tennessee (1-3) at Minnesota (3-1) — 4:25 p.m., CBS
Vikings QB Christian Ponder is the only starter in the NFL who hasn’t thrown an interception. The Titans are tied for second-worst turnover ratio in the league at minus-six. The Vikings are plus-one.
Buffalo (2-2) at San Francisco (3-1) — 4:25 p.m., CBS
The 49ers have not allowed a rushing TD in 11 straight home games, the longest active streak in the NFL. Bills QB Ryan Fitzpatrick leads the NFL with 12 touchdown passes. But he also has seven interceptions.
Denver (2-2) at New England (2-2) — 4:25, CBS
Tom Brady and Peyton Manning meet for the 13th time and the first since Manning joined the Broncos. Brady has won eight of 12 meetings. Broncos wide receivers Eric Decker, with 24 catches, and Demaryius Thomas, with 21, are tied for second in receptions by teammates this season. The Patriots are first, with Wes Welker and Brandon Lloyd catching 25 passes each.
San Diego (3-1) at New Orleans (0-4) — 8:20 p.m., NBC
Chargers TE Antonio Gates has 7,907 career yards receiving, and with 74 more yards will surpass Hall of Famers Jackie Smith (7,918) and Ozzie Newsome (7,980) for fourth-most career yards receiving by a tight end. The Saints are seeking to avoid their first 0-5 start since 1996, when they finished 3-13.
Houston (4-0) at New York (2-2) — Monday, 8:30 p.m., ESPN
A victory would make the Texans the first pro football team in Houston to start 5-0 since the Gamblers of the USFL in 1985. After scoring four offensive touchdowns in their season opener against Buffalo, the Jets have just two since. Jets QB Mark Sanchez’s 69.6 quarterback rating ranks 30th in NFL, just ahead of rookies Ryan Tannehill of Miami and Brandon Weeden of Cleveland.