San Diego (3-3) at Cleveland (1-6) - 1 p.m., CBS
San Diego QB Philip Rivers and TE Antonio Gates have combined for 51 career TDs, the most for a QB-TE tandem. The Browns lead the AFC with 10 interceptions.
Carolina (1-5) at Chicago (5-1) - 1 p.m., Fox
Chicago is giving up a league-low 13 points per game while scoring 27, eighth in the league. The Bears lead the NFL with 21 takeaways and their defense has five interception returns for TDs, tying the team record.
Seattle (4-3) at Detroit (2-4) - 1 p.m., Fox
Lions QB Matthew Stafford has five TDs and six INTs one season after throwing 41 TDs with 16 INTs. Seattle’s Leon Washington has returned seven kickoffs for TDs, trailing only Josh Cribbs in the NFL record books.
Jacksonville (1-5) at Green Bay (4-3) - 1 p.m., CBS
After scoring 57 points in their first three games, the Packers have scored 127 in the last four. The Jaguars have not scored a second-half TD in their last three games.
Indianapolis (3-3) at Tennessee (3-4) - 1 p.m., CBS
Reggie Wayne is averaging an AFC-best 111 yards receiving per game. He needs three catches to have 50 for the 10th straight season. Titans WR Kendall Wright leads all rookies with 36 catches.
Atlanta (6-0) at Philadelphia (3-3) - 1 p.m., Fox
The Falcons are 27-0 when QB Matt Ryan has a passer rating of 100 or higher. The Eagles have no sacks in their past three games. They led the NFL with 50 last year.
Miami (3-3) at New York Jets (3-4) - 1 p.m., CBS
The Miami defense leads the NFL by allowing opponents a third-down conversion rate of just 25.8 percent. Jets RB Shonn Greene is 7 for 7 on third-and-one attempts, best in the NFL.
New England (4-3) at St. Louis (3-4) - 1 p.m., CBS
This will be the NFL’s sixth regular season game played overseas (London). The Patriots won the second game played in London, beating Tampa Bay, 35-7, in 2009.
Washington (3-4) at Pittsburgh (3-3) - 1 p.m., Fox
Washington QB Robert Griffin III and RB Alfred Morris have rushed for combined 1,126 yards, or more than 30 other teams through first seven weeks of season. The Steelers are 13-1 against rookie starting quarterbacks since Dick LeBeau returned as defensive coordinator in 2004.
Oakland (2-4) at Kansas City (1-5) - 4:05 p.m., CBS
Kansas City has not led in regulation this season. Its only win came on a field goal in overtime at New Orleans. The Chiefs have lost four games by 16 points or more. Raiders RB Darren McFadden had 164 yards rushing and a touchdown in the first game between the teams. In five games since, he’s been held to 152 yards and one score.
New York Giants (5-2) at Dallas (3-3) - 4:25 p.m., Fox
Eli Manning has started 126 consecutive regular season games, the longest streak by a quarterback. Tony Romo is the seventh starting quarterback for the Cowboys since Manning’s streak began Nov. 21, 2004. In 16 career games against the Giants, Dallas LB DeMarcus Ware has 103 tackles, 13.5 sacks, 18 pressures and five forced fumbles. All but one sack is against Manning.
New Orleans (2-4) at Denver (3-3) - 8:30 p.m., NBC
The Broncos have outscored opponents, 79-6, in the fourth quarter. The Saints have allowed 2,793 yards over their first six games, the most since 1950. Saints DE Junior Galette has four sacks over the past four games. Saints WR Marques Colston has five touchdowns in the past three games.
San Francisco (5-2) at Arizona (4-3) - Monday, 8:30 p.m., ESPN
San Francisco QB Alex Smith has thrown five interceptions, the same number he threw last season. San Francisco is second in the NFL in yards rushing with 1,246. Arizona’s defense, ranked seventh in the NFL, is just 20th against the run. An Arizona win would snap a three-game slide and tie the Cardinals with 49ers atop the NFC West.