Buffalo Bills (3-4) at Houston Texans (6-1) - 1 p.m., CBS
The Bills lead the AFC in average yards per carry (5.3). RB C.J. Spiller is averaging an NFL-best 7.26 yards per carry. Houston DE J.J. Watt leads the NFL in sacks (91 / 2) and tackles for a loss (15).
Baltimore Ravens (5-2) at Cleveland Browns (2-6) - 1 p.m. CBS
The Ravens are on a 10-game winning streak in the AFC North, the longest current division streak in the league. They are playing a stretch of four of five games on the road. Browns rookie QB Brandon Weeden has just one interception in his past three games, after throwing nine in first five. Cleveland’s Phil Dawson is 12 of 12 on field goals.
Carolina Panthers (1-6) at Washington Redskins (3-5) - 1 p.m., FOX
The game features the last two Heisman Trophy winners: Carolina’s Cam Newton (2010) from Auburn and Washington’s Robert Griffin III (2011) from Baylor. Carolina has lost five straight, including its last four by a combined 12 points. The Redskins have 1,330 yards rushing at the season’s midpoint, the second most for the franchise through eight games since 1970.
Chicago Bears (6-1) at Tennessee Titans (3-5) - 1 p.m., FOX
The Bears have returned six interceptions for TDs, the most of any team in NFL history through seven games. Tennessee’s Kendall Wright leads NFL rookies with 40 catches and had his third TD reception last week.
Denver Broncos (4-3) at Cincinnati Bengals (3-4) - 1 p.m., CBS
Peyton Manning has thrown for at least 300 yards and three TDs in each of his past four games, the first player to do so since Steve Young in 1998. Bengals WR A.J. Green has caught a TD pass in six straight games.
Detroit Lions (3-4) at Jacksonville Jaguars (1-6) - 1 p.m., FOX
The Jaguars are 0-3 at home and have been blown out in all three games, losing by combined score of 95-20. Lions RB Mikel Leshoure has 429 yards from scrimmage in five career starts.
Arizona Cardinals (4-4) at Green Bay Packers (5-3) - 1 p.m., FOX
Green Bay and Arizona share the NFL lead in sacks with 26 each. The Packers are the only team to have three wide receivers with 35-plus receptions: Randall Cobb (42); Jordy Nelson (40); and James Jones (36).
Miami Dolphins (4-3) at Indianapolis Colts (4-3) - 1 p.m., CBS
The Miami defense has allowed 18 points per game, fewest in the AFC. Indy QB Andrew Luck needs one 300-yard game to join Peyton Manning as the only QBs with four 300-yard games in their rookie season.
Minnesota Vikings (5-3) at Seattle Seahawks (4-4) - 4:05 p.m., FOX
A matchup of the top two running backs in the NFC. Minnesota’s Adrian Peterson leads the conference with 775 yards rushing; Seattle’s Marshawn Lynch is second at 757 yards.
Tampa Bay Buccaneers (3-4) at Oakland Raiders (3-4) - 4:05 p.m., FOX
Only three players remain from the two teams that faced each other in the 2003 Super Bowl: Bucs S Ronde Barber and Raiders K Sebastian Janikowski and P Shane Lechler.
Pittsburgh Steelers (4-3) at New York Giants (6-2) - 4:25 p.m., CBS
Pittsburgh leads the NFL with a 51.9 percent conversion rate on third down. RB Jonathan Dwyer has rushed for 100-plus yards in two straight games. Giants RB Ahmad Bradshaw has 408 yards and six touchdowns in his past four games. Victor Cruz’s 52 receptions are fourth best in the league; his seven touchdown catches are tied for first overall with the Packers’ James Jones.
Dallas Cowboys (3-4) at Atlanta Falcons (7-0) - 8:20 p.m., NBC
The Cowboys top the Falcons in total offense and total defense, but the defining stat is turnover ratio: Dallas is minus-11, Atlanta is plus-10. Cowboys QB Tony Romo and Falcons QB Matt Ryan have similar completion and yards passing numbers, but Romo has 13 interceptions and nine touchdown passes. Ryan has six interceptions and touchdowns.
Philadelphia Eagles (3-4) at New Orleans Saints (2-5) - 8:30 p.m., ESPN
Eagles QB Michael Vick has a 78.6 passer rating, his lowest since joining the team in 2009. New Orleans already has two more losses than it did all of last season, when it tied the franchise record with a 13-3 mark. The Eagles rank next-to-last in the NFL with nine sacks. The Saints are the first team since at least 1950 to give up more than 400 yards in seven consecutive games.