Former Barcelona coach Tito Vilanova died at age 45 after a prolonged battle against cancer. Vilanova was diagnosed with cancer of the salivary gland more than two years ago. (Lluis Gene/AFP/Getty Images)

Tito Vilanova, the soccer coach who succeeded Pep Guardiola at Barcelona and won the Spanish league title in his only season in charge, died April 25 in Barcelona. He was 45.

Barcelona announced his death on its Web site and said the cause was throat cancer.

As Guardiola’s assistant, Mr. Vilanova provided the tactical know-how that helped the coach build one of the best teams in the history of the sport, winning two Champions League titles.

Mr. Vilanova first became ill in November 2011 while still an assistant to Guardiola and took a leave of absence after surgery. Mr. Vilanova returned and took over from Guardiola the next season, when he led Barcelona to the Spanish league title with a record-tying 100 points.

Mr. Vilanova had a second tumor removed in December 2012 and traveled to New York several times during the season for further treatment before returning to the sidelines. In April 2013, Mr. Vilanova said he felt fine and “never thought about quitting.” He finished the season before suddenly being forced to resign following a relapse in July.

As an assistant, Mr. Vilanova helped Guardiola propel Barcelona into its most successful period and transform a team led by Argentine-born Lionel Messi into perhaps the world’s best.

With a team that also included several of the players that led Spain to the World Cup title in 2010, Barcelona won 14 of a possible 19 major trophies from 2008-12 under Guardiola before adding the league title with Mr. Vilanova in 2013.

Despite the league display, Mr. Vilanova was unable to win another Champions League title last season. Barcelona lost to eventual champion Bayern Munich 7-0 on total goals in the semifinals.

Mr. Vilanova also will be remembered for his role in a brawl in the 2010 Spanish Super Cup won by Barcelona, when Real Madrid coach Jose Mourinho poked him in the eye.

Francesc Vilanova i Bayó was born Sept. 17, 1968, in Bellcaire d’Empordà, in the Catalonia region of Spain.

As a young player, Mr. Vilanova was at Barcelona’s training academy from 1984-89 but never made it to the first team. Instead, he went on to play for clubs such as Celta Vigo and Mallorca before his career was cut short by a knee injury.

Mr. Vilanova then went into coaching and got a job with Barcelona’s youth players, tutoring current players Gerard Pique, Cesc Fabregas and Messi. Mr. Vilanova left to work as sport director at third-division club Terrassa before returning to Barcelona to take over the club’s “Barca B” feeder team.

Survivors include his wife, Montse Chaure, and two children. His son Adrian is currently in Barcelona’s youth academy.

— Associated Press