With California under a state of emergency, countries in Asia and the Middle East further restricting travel and some 300 million children facing school closures around the world, the coronavirus outbreak is spurring an escalating economic cost and increasing disruptions to everyday life.

A cruise ship carrying some 2,500 passengers, en route from Hawaii to San Francisco, was held off the coast for coronavirus testing. Two U.S. coronavirus cases, including the first U.S. patient to die outside Washington state, have suspected links to the ship. At least 20 people had fallen ill and will be tested for the virus. U.S. officials scrambled to devise a quarantine plan.

The Dow Jones industrial average dropped more than 1,000 points Thursday afternoon amid mounting signs of economic problems ahead.

China remains the worst-hit country overall, with deaths surpassing 3,000 and confirmed cases topping 80,000. President Xi Jinping on Thursday canceled a planned state visit to Japan. But the epidemic is now slowing in China, while other countries are seeing outbreaks grow rapidly. In South Korea, mass testing has turned up more than 6,000 cases; the virus has caused more than 40 deaths there. Italy has confirmed more than 3,000 cases, along with more than 100 deaths.

The full extent of the outbreak remains hard to ascertain, in part because of political considerations. Hospital data obtained by The Washington Post suggests that Iran, which has reported 107 deaths, may be vastly underestimating the epidemic’s impact. North Korea, another authoritarian state, has released little information about possible cases.

The United States confirmed its 11th death from the outbreak Wednesday, along with more than 150 confirmed cases. Health experts have warned that the country may struggle to rapidly test thousands of Americans. President Trump downplayed worries Wednesday evening, telling Fox News that a 3.4 percent mortality rate announced by the World Health Organization was “false” and suggesting that it was under 1 percent. “This is really my hunch,” Trump said.

Here are the latest developments:

  • The Senate voted nearly unanimously to approve $8.3 billion in emergency spending for combating the coronavirus outbreak, sending the measure to the White House.
  • Tennessee confirmed its first coronavirus case and Illinois its fifth. Two more people were hospitalized with the virus in New York City, and the total number of infections in New York state rose to 22. The United Kingdom announced its first death from covid-19.
  • At a House committee hearing on the coronavirus, medical experts cautioned that the outbreak’s scale in the United States remains uncertain, although expanded testing should help define the scope.
  • Israeli and Palestinian authorities are closing off access to Bethlehem, a city revered by Christians, after new cases of coronavirus infections were reported in the Palestinian territories.
  • Italy’s prime minister unveiled an $8.4 billion stimulus package hoping to stave off some of the economic pain caused by the country’s widening outbreak.