The rapidly spreading coronavirus outbreak continued to upend life around the world Tuesday as more countries tightened quarantine measures.

All 50 states and the District of Columbia have confirmed cases of the novel coronavirus, after West Virginia announced its first patient Tuesday. At least 100 people infected with the virus have died in the United States, a toll that experts expect to rise quickly.

Schools, offices, bars, restaurants and many stores remain closed across major U.S. and European cities, and dozens of countries are shutting their borders or implementing mandatory self-isolation for travelers arriving from abroad.

Here are some other significant developments: