1999		John F. Kennedy Jr.: The only son of the slain president, his wife and sister-in-law were killed in a plane crash en route to his cousin Rory Kennedy's wedding in Martha's Vineyard.
1997		Michael Kennedy: The sixth child of the late Robert F. Kennedy was killed Dec. 31 in a skiing accident at Aspen, Colo. He was 39. Earlier that year, he was accused of having an affair with his family's teenage babysitter.
1991		William Kennedy Smith: The nephew of Sen. Edward M. Kennedy was acquitted Dec. 11 of raping a 30-year-old Jupiter, Fla., woman at the Kennedy estate in Palm Beach.
1986		Patrick J. Kennedy: The teenage son of Sen. Edward Kennedy, now a Democratic congressman for Rhode Island, spent time in a drug rehabilitation clinic for a cocaine addiction.
1984		David Kennedy: The fourth child of Robert Kennedy and Ethel Kennedy died from a drug overdose Easter weekend in a Palm Beach hotel room. He was 28.
1973		Edward Kennedy Jr.: The son of Sen. Edward Kennedy lost his right leg because of bone cancer. Joseph Kennedy: The eldest son of Robert F. Kennedy and Ethel Kennedy was involved in a car accident that left a female passenger paralyzed for life. He was convicted of reckless driving and fined $100.
1969		Edward M. Kennedy: The Massachusetts senator and brother of President John F. Kennedy and Robert Kennedy drove a car off a bridge on Chappaquiddick Island in Massachusetts July 18. Aide Mary Jo Kopechne was found dead later in the submerged vehicle.
1968		Robert F. Kennedy: The brother of President Kennedy and Sen. Edward Kennedy was shot and killed June 5 in Los Angeles after winning the California Democratic presidential primary. He was 42.
1963		John F. Kennedy: The son of Joseph and Rose Kennedy and the 35th president was assassinated in Dallas on Nov. 22. He was 46. Patrick Bouvier Kennedy: The son of President Kennedy was born prematurely and died three months before his father's assassination.
1948		Kathleen Kennedy: The daughter of Joseph and Rose Kennedy died in plane crash in 1948. She was 28.
1944		Joseph P. Kennedy Jr.: The eldest son of Joseph Kennedy, the family's patriarch, and his wife, Rose. His plane went down over the English Channel during World War II. He was 29.
1941		Rosemary Kennedy: The daughter of Joseph and Rose Kennedy was institutionalized because of retardation and a failed lobotomy.